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GGTI 2147
CAS No. 191102-87-1
GGTI 2147( —— )
Catalog No. M34080 CAS No. 191102-87-1
GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 790 | Get Quote |
|
| 5MG | 1112 | Get Quote |
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| 10MG | 1454 | Get Quote |
|
| 25MG | 1822 | Get Quote |
|
| 50MG | 2190 | Get Quote |
|
| 100MG | 2790 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameGGTI 2147
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NoteResearch use only, not for human use.
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Brief DescriptionGGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.
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DescriptionGGTI-2147 is a potent GGTase I inhibitor. GGTI-2147 blocks geranyl-geranylation of Rap1A and reduces the activity of Rac1 (one of substrates for GGTI) and ameliorates the OGD/R-induced neuronal apoptosis.GGTI-2147 can be used for neurodevelopmental disorders research, such as autism, depression, and schizophrenia.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetNF-κB
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RecptorNF-κB | Rho
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Research Area——
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Indication——
Chemical Information
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CAS Number191102-87-1
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Formula Weight470.56
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Molecular FormulaC28H30N4O3
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Purity>98% (HPLC)
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Solubility——
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SMILESC(N[C@H](C(OC)=O)CC(C)C)(=O)C1=C(C=C(NCC2=CN=CN2)C=C1)C=3C4=C(C=CC3)C=CC=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shangfeng Gao, et al. Astrocyte GGTI-mediated Rac1 prenylation upregulates NF-κB expression and promotes neuronal apoptosis following hypoxia/ischemia. Neuropharmacology. 2016 Apr:103:44-56.?
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