Cart
sales@molnova.com
GGTI 2147
CAS No. 191102-87-1
GGTI 2147( —— )
Catalog No. M34080 CAS No. 191102-87-1
GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 790 | Get Quote |
|
| 5MG | 1112 | Get Quote |
|
| 10MG | 1454 | Get Quote |
|
| 25MG | 1822 | Get Quote |
|
| 50MG | 2190 | Get Quote |
|
| 100MG | 2790 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameGGTI 2147
-
NoteResearch use only, not for human use.
-
Brief DescriptionGGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.
-
DescriptionGGTI-2147 is a potent GGTase I inhibitor. GGTI-2147 blocks geranyl-geranylation of Rap1A and reduces the activity of Rac1 (one of substrates for GGTI) and ameliorates the OGD/R-induced neuronal apoptosis.GGTI-2147 can be used for neurodevelopmental disorders research, such as autism, depression, and schizophrenia.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayApoptosis
-
TargetNF-κB
-
RecptorNF-κB | Rho
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number191102-87-1
-
Formula Weight470.56
-
Molecular FormulaC28H30N4O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC(N[C@H](C(OC)=O)CC(C)C)(=O)C1=C(C=C(NCC2=CN=CN2)C=C1)C=3C4=C(C=CC3)C=CC=C4
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Shangfeng Gao, et al. Astrocyte GGTI-mediated Rac1 prenylation upregulates NF-κB expression and promotes neuronal apoptosis following hypoxia/ischemia. Neuropharmacology. 2016 Apr:103:44-56.?
molnova catalog
related products
-
1-Isomangostin
1-Isomangostin has cytotoxic and anticomplementary activities.
-
5-hydroxy-78-dimetho...
5-hydroxy-78-dimethoxyflavone has anti-hypoxia activity it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-78-dimethoxyflavone significantly inhibits the transcriptional activity of NF-kappaB in LPS/IFN-gamma stimulated RAW 264.7 macrophages.
-
3-Sialyllactose sodi...
3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis. 3'-Sialyllactose sodium reduces stressor-induced anxiety-like behaviors and can be used in studies of inflammation and arthritis.
